By Michael Briggs and Maxine Briggs (Auth.)
ISBN-10: 0433042257
ISBN-13: 9780433042259
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Example text
Retinol (vitamin A) Night-blindness, xerophthalmia, and other signs of deficiency. Acne vulgaris, and other skin conditions. Hyperthyroidism. 2. Calciferol (vitamin D) Rickets. Hypoparathyroidism. Lupus vulgaris. 3. Tocopherols (vitamin E) 4. Vitamin K Intermittent claudication. Megaloblastic anaemia. 5. Ascorbic acid (vitamin C) Scurvy and other deficiency signs. 6. Thiamine Beri-beri, and other forms of neuritis. 7. Riboflavin Deficiency signs, dermatitis, glossitis, etc. 8. Pyridoxine Deficiency signs, dermatitis, anaemias, alcoholism, Raynaud's disease, etc.
Editor) (1971) Drug Metabolism in Man. Annals of t h e New York A c a d e m y of Sciences, Vol. 1 7 9 . 48 The chemistry and metabolism of drugs and toxins 4. Williams R. T. (1959) Detoxication Mechanisms London: John Wiley Ltd. 5. La Du B. , Mandel H. G. and Way E. L. (editors) (1971) Fundamentals of Drug Metabolism and Drug Disposition Baltimore: Williams & Wilkins. Chapter 2 BIOCHEMISTRY OF DRUGS I. TYPES OF PHARMACEUTICAL* 1. Introduction The study of drugs, in all their aspects, is known as "Pharmacology" (Greek, Pharmakon, meaning a "a medicine"), though the term "Pharmacognosy" is sometimes used interchangeably.
Most of the remainder appears in bile and, eventually, faeces. Many of these steroids are poorly absorbed in the intestines and only between 30 and 60% of an oral dose may enter the blood. Aromatization of the A-ring had been reported for the estrane compounds, but not for the pregnanes. However, saturation of 4-ene and 3-one probably occurs in both series, with formation of 3a- and 3j3-hydroxy compounds in both 5a- and 5j3-series. Almost all steroid metabolites are excreted as glucuronate or sulphate conjugates.